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Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review
Author(s) -
Panahi Yunes,
Fazlolahzadeh Omid,
Atkin Stephen L.,
Majeed Muhammed,
Butler Alexandra E.,
Johnston Thomas P.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27096
Subject(s) - curcumin , bioavailability , acne , psoriasis , pharmacology , skin cancer , skin aging , polyphenol , medicine , antioxidant , chemistry , cancer , dermatology , biochemistry
Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti‐inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability. In this regard, the present review is focused on recent studies concerning the use of curcumin for the treatment of skin diseases, as well as offering new and efficient strategies to optimize its pharmacokinetic profile and increase its bioavailability.