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Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation
Author(s) -
Wang Biao,
Wen Hao,
Smith Wanli,
Hao Dingjun,
He Baorong,
Kong Lingbo
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27090
Subject(s) - melatonin , mesenchymal stem cell , adipogenesis , microbiology and biotechnology , biology , stem cell , chondrogenesis , bone marrow , adipose tissue , cellular differentiation , receptor , signal transduction , immunology , neuroscience , endocrinology , genetics , gene
Melatonin’s therapeutic potential has been highly underestimated because its biological functional roles are diverse and relevant mechanisms are complicated. Among the numerous biological activities of melatonin, its regulatory effects on pluripotent mesenchymal stem cells (MSCs), which are found in bone marrow stem cells (BMSCs) and adipose tissue (AD‐MSC), have been recently proposed, which has received increasingly more attention in recent studies. Moreover, receptor‐dependent and receptor‐independent responses to melatonin are identified to occur in these cells by regulating signaling pathways, which drive the commitment and differentiation of MSCs into osteogenic, chondrogenic, or adipogenic lineages. Therefore, the aim of our current review is to summarize the evidence related to the utility of melatonin as a regulatory agent by focusing on its relationship with the differentiation of MSCs. In particular, we aimed to review its roles in promoting osteogenic and chondrogenic differentiation and the relevant signaling cascades involved. Also, the roles that melatonin and, particularly, its receptors play in these processes are highlighted.