Premium
A cellular perspective of adipogenesis transcriptional regulation
Author(s) -
KuriHarcuch Walid,
VelezdelValle Cristina,
VazquezSandoval Alfredo,
HernándezMosqueira Claudia,
FernandezSanchez Veronica
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27060
Subject(s) - adipogenesis , adipose tissue , microbiology and biotechnology , transcription factor , biology , transcriptional regulation , 3t3 l1 , adipokine , cellular differentiation , lipid droplet , endocrinology , genetics , leptin , obesity , gene
Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3‐F442A during 1974–1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3‐L1 and 3T3‐F442A cells that have provided essential data on adipose biology.