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Regulation of human mitogen‐activated protein kinase 15 (extracellular signal‐regulated kinase 7/8) and its functions: A recent update
Author(s) -
Lau Andy T. Y.,
Xu YanMing
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27053
Subject(s) - protein kinase a , kinase , microbiology and biotechnology , mitogen activated protein kinase kinase , map kinase kinase kinase , extracellular signal regulated kinases , ask1 , extracellular , mitogen activated protein kinase , chemistry , biology
Mitogen‐activated protein kinase 15 (MAPK15), originally also known as extracellular signal‐regulated kinase 7/8, is the most recently identified atypical MAPK and the least studied so far. Examinations of the role of MAPK15 in various cell lines and model systems indicate that MAPK15 participates in a variety of cellular activities such as promoting cell proliferation, cell transformation, and apoptosis; stimulating autophagy; regulating cell division, ciliogenesis, and protein secretion; and maintaining genome stability. As multiple roles of MAPK15 were observed among these studies, therefore, it remains unclear whether MAPK15 acts as a proto‐oncogene or tumor suppressor. Here, the recent literature on human MAPK15 and the resulting functions will be discussed.