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Infection‐associated epigenetic alterations in gastric cancer: New insight in cancer therapy
Author(s) -
Fattahi Sadegh,
KosariMonfared Mohadeseh,
Ghadami Elham,
Golpour Monireh,
Khodadadi Parastoo,
Ghasemiyan Mohammad,
AkhavanNiaki Haleh
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27030
Subject(s) - epigenetics , cancer , epigenetic therapy , dna methylation , histone , biology , cancer epigenetics , cancer research , bioinformatics , medicine , immunology , dna , genetics , gene expression , histone methyltransferase , gene
Gastric cancer risk is higher for malignancies motivated by bacterial and viral infections. Epigenetic abnormalities including DNA methylation, histone modifications, and noncoding RNAs are important regulatory key players in gastric cancer development in infected patients. Epigenetic memory restoration is an extremely interesting phenomenon which should be considered in therapeutic approaches. In vitro and in vivo antiviral treatments in combination with epigenetic therapeutic strategies along with standard chemotherapy revealed promising outcomes in gastric cancer prevention and treatment. This review summarizes our current understanding of the gastric cancer infections and epigenetic alterations caused by these agents. We focus on studies highlighting recent advances in epigenetic restoration by target specific drugs and present also a comprehensive overview of effective antiviral drug treatments against gastric cancer.