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Therapeutic potential of microRNAs in osteoporosis function by regulating the biology of cells related to bone homeostasis
Author(s) -
Zhao Wenhua,
Shen Gengyang,
Ren Hui,
Liang De,
Yu Xiang,
Zhang Zhida,
Huang Jinjing,
Qiu Ting,
Tang Jingjing,
Shang Qi,
Yu Peiyuan,
Wu Zixian,
Jiang Xiaobing
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26939
Subject(s) - microrna , osteoporosis , biology , mechanism (biology) , homeostasis , regulation of gene expression , function (biology) , microbiology and biotechnology , gene , bioinformatics , genetics , endocrinology , philosophy , epistemology
MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes through the posttranscriptional regulation of gene expression. Recently, deregulation of the miRNA‐mediated mechanism has emerged as an important pathological factor in osteoporosis. However, a detailed molecular mechanism between miRNAs and osteoporosis is still not available. In this review, the roles of miRNAs in the regulation of cells related to bone homeostasis as well as miRNAs that deregulate in human or animal are discussed. Moreover, the miRNAs that act as clusters in the biology of cells in the bone microenvironment and the difference of some important miRNAs for bone homeostasis between bone and other organs are mentioned. Overall, miRNAs that contribute to the pathogenesis of osteoporosis and their therapeutic potential are considered.