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YAP and TAZ, the conductors that orchestrate eye development, homeostasis, and disease
Author(s) -
Zhu JingYi,
Lin Sen,
Ye Jian
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26870
Subject(s) - hippo signaling pathway , transcription factor , morphogenesis , biology , eye development , microbiology and biotechnology , pdz domain , signal transduction , function (biology) , computational biology , bioinformatics , neuroscience , genetics , gene
Yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) are transcriptional coactivators established as a nexus in numerous signaling pathways, notably in Hippo signaling. Previous research revealed multifarious function of YAP and TAZ in oncology and cardiovasology. Recently, the focus has been laid on their pivotal role in eye morphogenesis and homeostasis. In this review, we synthesize advances of YAP and TAZ function during eye development in different model organisms, introduce their function in different ocular tissues and eye diseases, and highlight the potential for therapeutic interventions.