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ARHGAP21 as a master regulator of multiple cellular processes
Author(s) -
Rosa Lucas R. O.,
Soares Gabriela M.,
Silveira Leonardo R.,
Boschero Antonio C.,
BarbosaSampaio Helena C. L.
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26829
Subject(s) - effector , microbiology and biotechnology , regulator , gtpase , biology , actin cytoskeleton , cell migration , cdc42 , gtpase activating protein , master regulator , golgi apparatus , cell , cytoskeleton , signal transduction , g protein , genetics , gene , transcription factor , endoplasmic reticulum
The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.