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Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance
Author(s) -
Mihanfar Aynaz,
Aghazadeh Attari Javad,
Mohebbi Iraj,
Majidinia Maryam,
Kaviani Mojtaba,
Yousefi Mehdi,
Yousefi Bahman
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26768
Subject(s) - ovarian cancer , cancer stem cell , cancer , multiple drug resistance , metastasis , stem cell , cancer research , medicine , biology , oncology , bioinformatics , drug resistance , genetics
Abstract The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies and solid tumors and the identification and isolation of ovarian cancer stem cells (OV‐CSCs) show that ovarian cancer also follows this hierarchical model. Gaining a better insight into CSC‐mediated resistance holds promise for improving current ovarian cancer therapies and prolonging the survival of recurrent ovarian cancer patients in the future. Therefore, in this review, we will discuss some important mechanisms by which CSCs can escape chemotherapy, and then review the recent and growing body of evidence that supports the contribution of CSCs to MDR in ovarian cancer.