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Application of induced pluripotent stem cell and embryonic stem cell technology to the study of male infertility
Author(s) -
Mahabadi Javad Amini,
Sabzalipour Hamed,
Bafrani Hassan Hassani,
Gheibi Hayat Seyed Mohammad,
Nikzad Hossein
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26757
Subject(s) - stem cell , embryonic stem cell , induced pluripotent stem cell , somatic cell , biology , adult stem cell , germ cell , microbiology and biotechnology , cell potency , infertility , regenerative medicine , immunology , genetics , pregnancy , gene
Stem cells (SCs) are classes of undifferentiated biological cells existing only at the embryonic, fetal, and adult stages that can divide to produce specialized cell types during fetal development and remain in our bodies throughout life. The progression of regenerative and reproductive medicine owes the advancement of respective in vitro and in vivo biological science on the stem cell nature under appropriate conditions. The SCs are promising therapeutic tools to treat currently of infertility because of wide sources and high potency to differentiate. Nevertheless, no effective remedies are available to deal with severe infertility due to congenital or gonadotoxic stem cell deficiency in prepubertal childhood. Some recent solutions have been developed to address the severe fertility problems, including in vitro formation of germ cells from stem cells, induction of pluripotency from somatic cells, and production of patient‐specific pluripotent stem cells. There is a possibility of fertility restoration using the in vitro formation of germ cells from somatic cells. Accordingly, the present review aimed at studying the literature published on the medical application of stem cells in reproductive concerns.