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TUSC7: A novel tumor suppressor long non‐coding RNA in human cancers
Author(s) -
Li Na,
Shi Ke,
Li Wei
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26544
Subject(s) - suppressor , carcinogenesis , cancer research , biomarker , biology , tumor suppressor gene , gene , tumor progression , long non coding rna , rna , cell growth , genetics
Accumulating evidences has shown that tumor suppressor candidate 7 (TUSC7) as a putatively tumor suppressor gene in various tumors. The low‐expression of TUSC7 is related to poor prognosis, and increased the proliferation rate of tumor cells. Over‐expression of TUSC7 could suppress tumor cell proliferation, migration, invasion, and colony formation, suggesting that TUSC7 might be a diagnostic and prognostic biomarker, as well as therapeutic target. In this review, we summarized the molecular mechanism and clinical significance of TUSC7 in tumorigenesis, tumor progression, and prognosis.