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p120‐catenin is required for regulating epidermal proliferation, differentiation, and barrier function
Author(s) -
Xie Zhongjian,
Tang Yuanyuan,
Man MaoQiang,
Shrestha Chandrama,
Bikle Daniel D.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26535
Subject(s) - catenin , microbiology and biotechnology , function (biology) , barrier function , chemistry , biology , signal transduction , wnt signaling pathway
p120‐catenin (p120) is an important regulator in the function and stability of E‐cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability. These data suggest that p120 is required for suppressing epidermal proliferation, promoting epidermal differentiation and maintaining permeability barrier function of the epidermis.