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Characteristics of tendon derived stem cells according to different factors to induce the tendinopathy
Author(s) -
Kim Sun Jeog,
Song DaHyun,
Kim Sang Jun
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26475
Subject(s) - tendinopathy , tendon , stem cell , medicine , pathology , biology , microbiology and biotechnology
Tendon derived stem cells (TDSCs) have been used as a therapeutic agent and as a healing marker. However, there has been no study about the characteristics of TDSCs extracted from tendinopathic tendon tissues. The aim of this study was to find the different characteristics of TDSCs according to the factors to induce the tendinopathy. Five‐ and fifteen‐week old Sprague Dawley rats were used for this study and chemically‐induced and injury‐induced tendinopathy models were made depending on the age of the animal for different types of tendinopathy. TDSCs from chemically‐induced tendinopathy showed markedly low proliferation compared to those from age‐matched normal control and injury‐induced tendinopathy. In addition, TDSCs from chemically‐induced tendinopathy progressed to osteogenesis under an osteogenic differentiation environment more than those from other groups. In contrast, TDSCs from injury‐induced tendinopathy showed markedly high proliferation and high expression of type III collagen and α‐SMA compared to other groups. Adipogenic potentials in TDSCs from injury‐induced tendinopathy were also higher. These different characteristics might be helpful in the development new therapeutic agents for tendon regeneration according to different factors to induce the tendinopathy.