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The role of innate lymphoid cells in health and disease
Author(s) -
Mohammadi Hamed,
Sharafkandi Nadia,
Hemmatzadeh Maryam,
Azizi Gholamreza,
Karimi Mohammad,
JadidiNiaragh Farhad,
Baradaran Behzad,
Babaloo Zohreh
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26250
Subject(s) - innate lymphoid cell , immunology , immune system , inflammation , immunity , autoimmunity , innate immune system , biology , disease , psoriasis , context (archaeology) , acquired immune system , allergy , medicine , paleontology , pathology
Innate lymphoid cells (ILCs) are kind of innate immune cells which can be divided into three main subsets according to their cytokine release profile, transcription factors, and surface markers. ILCs affect the initial stages of immunity in response to microbes and participate in immunity, inflammation, and tissue repair. ILCs modulate immunity through resistance to the pathogens and regulation of autoimmune inflammation and metabolic homeostasis. Therefore dysregulation of ILCs may lead to chronic pathologies such as allergies (i.e., asthma), inflammation (i.e., inflammatory bowel disease), and autoimmunity (i.e., psoriasis, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, and ankylosing spondylitis). Regarding the critical role of ILCs in the regulation of immune system, the elucidation of their function in different conditions makes an interesting target for improvement of novel therapeutic approach to modulate an immune response in different disease context.