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Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their function
Author(s) -
Hu Ji,
Li Peng,
Song Yang,
Ge Yunxuan,
Meng Xiaoming,
Huang Cheng,
Li Jun,
Xu Tao
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26154
Subject(s) - hepatocellular carcinoma , pathogenesis , biomarker , metastasis , mechanism (biology) , nonalcoholic steatohepatitis , circular rna , biology , cancer research , function (biology) , computational biology , microrna , bioinformatics , cancer , medicine , pathology , gene , immunology , genetics , fatty liver , nonalcoholic fatty liver disease , disease , philosophy , epistemology
Hepatocellular carcinoma (HCC) is one of the most predominant subjects of liver malignancies, which arouses global concern in the recent years. Advanced studies have found that Circular RNAs (circRNAs) are differentially expressed in HCC, with its regulatory capacity in HCC pathogenesis and metastasis. However, the underlying mechanism remains largely unknown. In this review, we summarized the functions and mechanisms of those aberrantly expressed circRNAs in HCC tissues. We hope to enlighten more comprehensive studies on the detailed mechanisms of circRNAs and explore their potential values in clinic applications. It revealed that hsa_circ_0004018 can be used as a potential biomarker in HCC diagnosis, with its superior sensitivity to alpha‐fetoprotein (AFP). Notably, the correlation of circRNA abundance in the proliferation of liver regeneration (LR) has recently been clarified and different circRNA profiles served as candidates for nonalcoholic steatohepatitis (NASH) diagnosis also be discussed. Therefore, the improved understanding of circRNAs in HCC pathogenesis and metastasis proposed a novel basis for the early diagnosis in HCC patients, which provides a useful resource to explore the pathogenesis of HCC.