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Humanized mouse models: Application to human diseases
Author(s) -
Ito Ryoji,
Takahashi Takeshi,
Ito Mamoru
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26045
Subject(s) - humanized mouse , human disease , genetically engineered , disease , biology , genetically modified organism , immunology , transgene , cancer research , computational biology , medicine , gene , immune system , pathology , genetics
Humanized mice are superior to rodents for preclinical evaluation of the efficacy and safety of drug candidates using human cells or tissues. During the past decade, humanized mouse technology has been greatly advanced by the establishment of novel platforms of genetically modified immunodeficient mice. Several human diseases can be recapitulated using humanized mice due to the improved engraftment and differentiation capacity of human cells or tissues. In this review, we discuss current advanced humanized mouse models that recapitulate human diseases including cancer, allergy, and graft‐versus‐host disease.