Premium
Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress
Author(s) -
Bahrami Afsane,
Khazaei Majid,
Hassanian Seyed Mahdi,
ShahidSales Soodabeh,
JoudiMashhad Mona,
Maftouh Mina,
Jazayeri Mir Hadi,
Parizade Mohammad Reza,
Ferns Gordon A.,
Avan Amir
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26041
Subject(s) - tumor microenvironment , colorectal cancer , metastasis , medicine , cancer , cancer research , immune system , mechanism (biology) , disease , immunology , philosophy , epistemology
Colorectal cancer (CC) is often diagnosed at a late stage when tumor metastasis may have already occurred. Current treatments are often ineffective in metastatic disease, and consequently late diagnosis is often associated with poor outcomes in CC. Alternative strategies are therefore urgently required. An interaction between epithelial cancer cells and their tissue microenvironment is a contributor to metastasis, and therefore recent studies are beginning to focus on the properties of the tumor microenvironment and the mechanism by which the metastatic cells exploit the tumor microenvironment for survival, immune evasion, and growth. We have reviewed the development of the combined therapeutic approaches that have focused on targeting the microenvironment of CC.