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The genetic factors contributing to the development of Wilm's tumor and their clinical utility in its diagnosis and prognosis
Author(s) -
Bahrami Afsane,
Joodi Marjan,
Maftooh Mina,
Ferns Gordon A.,
M. Ahmadi Mehrdad,
Hassanian Seyed M.,
Avan Amir
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26021
Subject(s) - epigenetics , risk stratification , bioinformatics , biology , medicine , gene , intensive care medicine , oncology , genetics
Mutations in the Wilm's tumor 1 ( WT1 ) gene are associated with a wide spectrum of renal manifestations, ultimately leading to end‐stage kidney failure. There is an inadequate understanding of the molecular functions of WT1 in renal development, and this has limited the potential for therapeutic interventions in WT1 ‐related diseases. In this review, we discuss the existing data on the genetic and epigenetic abnormalities that have been described in WTs and their potential utility as biomarkers for risk stratification, prediction and prognosis in patients with WTs.