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Genetic susceptibility in cervical cancer: From bench to bedside
Author(s) -
Bahrami Afsane,
Hasanzadeh Malihe,
Shahidsales Soodabeh,
Farazestanian Marjaneh,
Hassanian Seyed Mahdi,
Moetamani Ahmadi Mehrdad,
Maftouh Mina,
Gharib Masoumeh,
Yousefi Zohreh,
Kadkhodayan Sima,
Ferns Gordon A.,
Avan Amir
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26019
Subject(s) - genome wide association study , cervical cancer , genetic association , cervix , biology , cancer , genetic predisposition , malignancy , genetics , candidate gene , host factors , single nucleotide polymorphism , gene , bioinformatics , oncology , medicine , genotype , virus
Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties of the HPV and host factors. Host‐related genetic factors, including the presence of susceptibility loci for cervix tumor is substantial importance. Preclinical and genome‐wide association studies (GWAS) have reported the associations of genetic variations in several susceptibility loci for the development of cervical cancer. However, many of these reports are inconsistent. In this review, we discuss the findings to date of candidate gene association studies, and GWAS in cervical cancer. The associations between these genetic variations with response to chemotherapy are also discussed.