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Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling
Author(s) -
Shears Stephen B.
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26017
Subject(s) - inositol , signal transduction , cell signaling , inositol phosphate , microbiology and biotechnology , chemistry , biochemistry , metabolism , cell , homeostasis , metabolic pathway , enzyme , cell metabolism , phosphate , biology , receptor
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most concentrated three‐dimensional array of phosphate groups in Nature; up to eight phosphates are crammed around a six‐carbon inositol ring. This review discusses the physico‐chemical properties of these unique molecules, and their mechanisms of action. Also provided is information on the enzymes that regulate the levels and hence the signaling properties of these molecules. This review pursues the idea that many of the biological effects of inositol pyrophosphates can be rationalized by their actions at the interface of cell signaling and metabolism that is essential to cellular and organismal homeostasis.