NAD + : A big player in cardiac and skeletal muscle remodeling and aging

In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti‐aging molecule. A paper in science by Zhang et al. ([Zhang, H., 2016]) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. ([Cox, M. J., 2002]) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. ([Cox, M. J., 2002]) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti‐aging and anti‐oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.