Premium
NAD + : A big player in cardiac and skeletal muscle remodeling and aging
Author(s) -
Chaturvedi Pankaj,
Tyagi Suresh C.
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.26014
Subject(s) - nad+ kinase , mitochondrion , heart failure , cardiac muscle , skeletal muscle , chemistry , medicine , microbiology and biotechnology , biology , endocrinology , biochemistry , enzyme
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti‐aging molecule. A paper in science by Zhang et al. ([Zhang, H., 2016]) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. ([Cox, M. J., 2002]) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. ([Cox, M. J., 2002]) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti‐aging and anti‐oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.