Premium
Therapeutic application of multipotent stem cells
Author(s) -
Mirzaei Hamed,
Sahebkar Amirhossein,
Sichani Laleh Shiri,
Moridikia Abdullah,
Nazari Sara,
Sadri Nahand Javid,
salehi Hossein,
Stenvang Jan,
Masoudifar Aria,
Mirzaei Hamid R.,
Jaafari Mahmoud R.
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25990
Subject(s) - multipotent stem cell , stem cell , biology , microbiology and biotechnology , stem cell therapy , cell type , cell therapy , cell , progenitor cell , genetics
Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self‐renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti‐inflammatory and anti‐apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.