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ABC of multifaceted dystrophin glycoprotein complex (DGC)
Author(s) -
Bhat Hina F.,
Mir Saima S.,
Dar Khalid B.,
Bhat Zuhaib F.,
Shah Riaz A.,
Ganai Nazir A.
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25982
Subject(s) - dystrophin , biology , glycoprotein , microbiology and biotechnology , signal transduction , cell , computational biology , neuroscience , genetics , duchenne muscular dystrophy
Dystrophin protein in association with several other cellular proteins and glycoproteins leads to the formation of a large multifaceted protein complex at the cell membrane referred to as dystrophin glycoprotein complex (DGC), that serves distinct functions in cell signaling and maintaining the membrane stability as well as integrity. In accordance with this, several findings suggest exquisite role of DGC in signaling pathways associated with cell development and/or maintenance of homeostasis. In the present review, we summarize the established facts about the various components of this complex with emphasis on recent insights into specific contribution of the DGC in cell signaling at the membrane. We have also discussed the recent advances made in exploring the molecular associations of DGC components within the cells and the functional implications of these interactions. Our review would help to comprehend the composition, role, and functioning of DGC and may lead to a deeper understanding of its role in several human diseases.