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Role of Wnt/β‐catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer
Author(s) -
Rahmani Farzad,
Avan Amir,
Hashemy Seyed Isaac,
Hassanian Seyed Mahdi
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25897
Subject(s) - wnt signaling pathway , microrna , colorectal cancer , cancer research , metastasis , angiogenesis , cancer , signal transduction , mouse model of colorectal and intestinal cancer , catenin , suppressor , pathogenesis , biology , medicine , immunology , gene , microbiology and biotechnology , genetics
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras‐Wnt signaling axis is over‐activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β‐catenin signaling. This review summarizes the current knowledge about the role of Wnt/β‐catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.