Premium
The prognostic value of MGMT promoter methylation in glioblastoma: A meta‐analysis of clinical trials
Author(s) -
Binabaj Maryam Moradi,
Bahrami Afsane,
ShahidSales Soodabeh,
Joodi Marjan,
Joudi Mashhad Mona,
Hassanian Seyed Mahdi,
Anvari Kazem,
Avan Amir
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25896
Subject(s) - temozolomide , oncology , medicine , methyltransferase , meta analysis , o 6 methylguanine dna methyltransferase , methylation , glioblastoma , dna methylation , cochrane library , biomarker , clinical trial , progression free survival , overall survival , cancer research , chemotherapy , biology , gene , genetics , gene expression
The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to be associated with resistance to alkylating agents such as Temozolomide which is being used in treatment of patients with glioblastoma (GBM). Therefore, we evaluated the associations between MGMT promoter methylation and prognosis of patients with glioblastoma (GBM). Data were extracted from publications in Embase, PubMed, and the Cochrane Library. Data on overall survival (OS), progression‐free survival (PFS), and MGMT methylation status were obtained and 4,097 subjects were enrolled. Data from 34 studies showed that MGMT methylated patients had better OS, compared to GBM unmethylated patients (pooled HRs, 0.494; 95%CI 0.412–0.591; p = 0.001). Meta‐analysis of 10 eligible studies reporting on PFS, demonstrated that MGMT promoter methylation was not significantly associated with better PFS (pooled HRs, 0.653; 95%CI 0.414–1.030; p = 0.067). GBM patients with MGMT methylation were associated with longer overall survival, although this effect was not detected for PFS. Moreover, we performed further analysis in patients underwent a comprehensive imaging evaluation. This data showed a significant association with better OS and PFS, although further studies are warranted to assess the value of emerging marker in prospective setting in patients with glioblastoma as a risk stratification biomarker in clinical management of the patients.