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Cytokine networks and their association with Helicobacter pylori infection in gastric carcinoma
Author(s) -
Bagheri Vahid,
Memar Bahram,
Momtazi Amir Abbas,
Sahebkar Amirhossein,
Gholamin Mehran,
Abbaszadegan Mohammad Reza
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25822
Subject(s) - inflammation , helicobacter pylori , cytokine , immunology , cancer , disease , immunity , biology , gastric mucosa , immune system , medicine , stomach , pathology
Cytokine networks as dynamic networks are pivotal aspects of tumor immunology, especially in gastric cancer (GC), in which infection, inflammation, and antitumor immunity are key elements of disease progression. In this review, we describe functional roles of well‐known GC‐modulatory cytokines, highlight the functions of cytokines with more recently described roles in GC, and emphasize the therapeutic potential of targeting the complex cytokine milieu. We also focus on the role of Helicobacter pylori (HP)‐induced inflammation in GC and discuss how HP‐induced chronic inflammation can lead to the induction of stem cell hyperplasia, morphological changes in gastric mucosa and GC development.