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C‐Met as a potential target for the treatment of gastrointestinal cancer: Current status and future perspectives
Author(s) -
Bahrami Afsane,
Shahidsales Soodabeh,
Khazaei Majid,
GhayourMobarhan Majid,
Maftouh Mina,
Hassanian Seyed Mahdi,
Avan Amir
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25794
Subject(s) - crizotinib , medicine , cancer , cancer research , gastrointestinal cancer , targeted therapy , c met , lung cancer , clinical trial , metastasis , oncology , hepatocyte growth factor , colorectal cancer , receptor , malignant pleural effusion
Aberrant activation of the HGF/c‐Met signalling pathways is shown to be related with cell proliferation, progression, metastasis, and worse prognosis in several tumor types, including gastrointestinal cancers, suggesting its value as a stimulating‐target for cancer‐therapy. Several approaches have been developed for targeting HGF and/or c‐Met, and one of them, crizotinib (dual c‐Met/ALK inhibitor), is recently been approved by FDA for lung‐cancers with ALK‐rearrangement. The main aim of current review is to give an overview on the role of c‐Met/HGF pathway in gastrointestinal cancer, in preclinical and clinical trials. Although several important matters is still remained to be elucidated on the molecular pathways underlying the antitumor effects of this therapy in gastrointestinal‐cancers. Further investigations are warranted to recognize the main determinants of the activity of c‐Met inhibitors, for parallel targeting signalling pathway associated/activated via MET/HGF pathway or in response to the cell resistance to anti‐c‐Met agents. Additionally, identification of patients that might benefit from therapy could help to increase the selectivity and efficacy of the therapy.