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MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy
Author(s) -
Mirzaei Hamed,
Momeni Fatemeh,
Saadatpour Leila,
Sahebkar Amirhossein,
Goodarzi Mohammad,
Masoudifar Aria,
Kouhpayeh Shirin,
Salehi Hossein,
Mirzaei Hamid Reza,
Jaafari Mahmoud Reza
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25787
Subject(s) - stroke (engine) , microrna , microvesicles , disease , medicine , bioinformatics , stromal cell , biomarker , intensive care medicine , biology , gene , mechanical engineering , biochemistry , engineering
Stroke is a life‐threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell‐derived exosomes containing miRNAs can be used for monitoring and treatment of various diseases such as stroke. Here, we summarized various aspects of miRNA applications in different stages of stroke.