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Novel circulating biomarkers for non‐alcoholic fatty liver disease: A systematic review
Author(s) -
Sahebkar Amirhossein,
Sancho Elena,
Abelló David,
Camps Jordi,
Joven Jorge
Publication year - 2018
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25779
Subject(s) - fatty liver , biomarker , liver biopsy , gold standard (test) , medicine , disease , biopsy , population , gastroenterology , pathology , bioinformatics , intensive care medicine , biology , biochemistry , environmental health
Currently, a liver biopsy remains the only reliable way to precisely diagnose non‐alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis, and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently. We highlight α‐ketoglutarate and CK18‐F as currently the best potential biomarker of NAFLD. However, due to methodological differences, we propose the implementation of international, multicenter, multiethnic studies with larger population size, and biopsy proven NAFLD diagnosis to analyze and compare α‐ketoglutarate and CK18‐F as potential biomarkers of the silent evolution of NAFLD.