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Roles of Notch1 Signaling in Regulating Satellite Cell Fates Choices and Postnatal Skeletal Myogenesis
Author(s) -
Shan Tizhong,
Xu Ziye,
Wu Weiche,
Liu Jiaqi,
Wang Yizhen
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25730
Subject(s) - myogenesis , skeletal muscle , microbiology and biotechnology , biology , regeneration (biology) , myocyte , satellite , cell , signal transduction , endocrinology , genetics , engineering , aerospace engineering
Adult skeletal muscle stem cells, also called satellite cells, are indispensable for the growth, maintenance, and regeneration of the postnatal skeletal muscle. Satellite cells, predominantly quiescent in mature resting muscles, are activated after skeletal muscle injury or degeneration. Notch1 signaling is an evolutionarily conserved pathway that plays crucial roles in satellite cells homeostasis and postnatal skeletal myogenesis and regeneration. Activation of Notch1 signaling promotes the muscle satellite cells quiescence and proliferation, but inhibits differentiation of muscle satellite cells. Notably, the new roles of Notch1 signaling during late‐stage of skeletal myogenesis including in post‐differentiation myocytes and post‐fusion myotubes have been recently reported. Here, we mainly review and discuss the regulatory roles of Notch1 in regulating satellite cell fates choices and skeletal myogenesis. J. Cell. Physiol. 232: 2964–2967, 2017. © 2016 Wiley Periodicals, Inc.