Premium
Factor Xa Signaling Contributes to the Pathogenesis of Inflammatory Diseases
Author(s) -
Ebrahimi Safieh,
Rezaei Sara,
Seiri Parvaneh,
Ryzhikov Mikhail,
Hashemy Seyed Isaac,
Hassanian Seyed Mahdi
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25714
Subject(s) - pathogenesis , signal transduction , receptor , inflammation , protease , cell signaling , tissue factor , immunology , cancer research , biology , coagulation , medicine , microbiology and biotechnology , enzyme , biochemistry
The coagulation protease Factor Xa (FXa) triggers a variety of signaling pathways through activation of protease‐activated receptors (PARs) and non‐PAR receptors. FXa‐mediated signaling is strongly implicated in the pathogenesis of several inflammatory diseases including fibrosis, cardiovascular diseases, and cancer. Thus, targeting of FXa can have great clinical significance in terms of the treatment of these disorders. This review summarizes the current knowledge about the mechanism of FXa signaling in cellular and animal systems under (patho) physiological conditions for a better understanding and hence a better management of FXa‐induced disorders. J. Cell. Physiol. 232: 1966–1970, 2017. © 2016 Wiley Periodicals, Inc.