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Condensin Regulation of Genome Architecture
Author(s) -
Rana Vibhuti,
Bosco Giovanni
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25702
Subject(s) - genome , architecture , computational biology , biology , condensin , microbiology and biotechnology , genetics , dna , chromatin , gene , geography , cohesin , archaeology
Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied in mitosis but have recently emerged as important regulators of genome organization and gene expression during interphase. Here, we focus our discussion on recent findings on the molecular mechanism and how condensins are used to shape chromosomes during interphase. These findings suggest condensin activity during interphase is required for proper chromosome organization. J. Cell. Physiol. 232: 1617–1625, 2017. © 2016 Wiley Periodicals, Inc.