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Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes
Author(s) -
Shan Tizhong,
Liu Jiaqi,
Wu Weiche,
Xu Ziye,
Wang Yizhen
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25697
Subject(s) - adipogenesis , microbiology and biotechnology , adipocyte , progenitor cell , adipose tissue , mesenchymal stem cell , cellular differentiation , stromal cell , stem cell , biology , notch signaling pathway , signal transduction , endocrinology , cancer research , biochemistry , gene
Adipose tissues, composed with mature adipocytes and preadipocytic stromal/stem cells, play crucial roles in whole body energy metabolism and regenerative medicine. Mature adipocytes are derived and differentiated from mesenchymal stem cells (MSCs) or preadipocytes. This differentiation process, also called adipogenesis, is regulated by several signaling pathways and transcription factors. Notch1 signaling is a highly conserved pathway that is indispensable for stem cell hemostasis and tissue development. In adipocyte progenitor cells, Notch1 signaling regulates the adipogenesis process including proliferation and differentiation of the adipocyte progenitor cells in vitro. Notably, the roles of Notch1 signaling in beige adipocytes formation, adipose development, and function, and the whole body energy metabolism have been recently reported. Here, we mainly review and discuss the roles of Notch1 signaling in adipogenesis in vitro as well as in beige adipocytes formation, adipocytes dedifferentiation, and function in vivo. J. Cell. Physiol. 232: 1258–1261, 2017. © 2016 Wiley Periodicals, Inc.