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Role of Wnt5a in the Pathogenesis of Inflammatory Diseases
Author(s) -
Pashirzad Mehran,
Shafiee Mojtaba,
Rahmani Farzad,
BehnamRassouli Reihane,
Hoseinkhani Fatemeh,
Ryzhikov Mikhail,
Moradi Binabaj Maryam,
Parizadeh Mohammad Reza,
Avan Amir,
Hassanian Seyed Mahdi
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25687
Subject(s) - pathogenesis , medicine , biology , immunology
Wnt5a initiates pro‐inflammatory responses through activation of non‐canonical Wnt signaling pathway. Pro‐inflammatory functions of Wnt5a trigger pro‐inflammatory signaling cascades and increase secretion of pro‐inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611–1616, 2017. © 2016 Wiley Periodicals, Inc.