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Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle
Author(s) -
Lima Tanes I.,
Araujo Hygor N.,
Menezes Eveline S.,
Sponton Carlos H.,
Araújo Michel B.,
Bomfim Lucas H.M.,
Queiroz André L.,
Passos Madla A.,
e Sousa Thais Amaral,
Hirabara Sandro M.,
Martins Amanda R.,
Sampaio Helena C.L.B.,
Rodrigues Alice,
Curi Rui,
Carneiro Everardo M.,
Boschero Antônio C.,
Silveira Leonardo R.
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25645
Subject(s) - microbiology and biotechnology , microrna , biology , mitochondrion , skeletal muscle , mitochondrial biogenesis , translation (biology) , biogenesis , cell metabolism , signal transduction , cell , messenger rna , gene , endocrinology , genetics
Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non‐coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non‐vesicular circulating miRNAs exhibit a potential role as mediators of the cross‐talk between the skeletal muscle and other tissues/organs. In this review, we will focus on the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. J. Cell. Physiol. 232: 958–966, 2017. © 2016 Wiley Periodicals, Inc.