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Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle
Author(s) -
VanOudenhove Jennifer J.,
Grandy Rodrigo A.,
Ghule Prachi N.,
Lian Jane B.,
Stein Janet L.,
Zaidi Sayyed K.,
Stein Gary S.
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25567
Subject(s) - induced pluripotent stem cell , biology , embryonic stem cell , microbiology and biotechnology , endoderm , epigenetics , cell cycle , stem cell , cell potency , cellular differentiation , epiblast , cell , embryo , genetics , embryogenesis , gastrulation , gene
The cell cycle in pluripotent human embryonic stem cells is governed by unique mechanisms that support unrestricted proliferation and competency for endodermal, mesodermal, and ectodermal differentiation. The abbreviated G1 period with retention of uncompromised fidelity for genetic and epigenetic mechanisms operative in control of proliferation support competency for expansion of the pluripotent cell population that is fundamental for initial stages of development. Regulatory events during the G1 period of the pluripotent cell cycle are decisive for the transition from pluripotency to lineage commitment. Recent findings indicate that a G2 cell cycle pause is present in both endodermal and mesodermal lineage cells, and is obligatory for differentiation to endoderm. J. Cell. Physiol. 232: 1254–1257, 2017. © 2016 Wiley Periodicals, Inc.