Premium
Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic
Author(s) -
Spugnini Enrico P.,
Fais Stefano,
Azzarito Tommaso,
Baldi Alfonso
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25505
Subject(s) - electrochemotherapy , veterinary medicine , medicine , medical physics , surgery , bleomycin , chemotherapy
Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490–495, 2017. © 2016 Wiley Periodicals, Inc.