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Role of thrombin in the pathogenesis of central nervous system inflammatory diseases
Author(s) -
Ebrahimi Safieh,
Jaberi Najme,
Avan Amir,
Ryzhikov Mikhail,
Keramati Mohammad Reza,
Parizadeh Mohammad Reza,
Hassanian Seyed Mahdi
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25501
Subject(s) - proinflammatory cytokine , thrombin , chemokine , pathogenesis , immunology , inflammation , neuroinflammation , medicine , biology , platelet
Thrombin initiates proinflammatory signaling responses through activation of protease‐activated receptors (PARs) in in vitro and in vivo systems. Proinflammatory signaling function of thrombin increases secretion of proinflammatory cytokines and chemokines, triggers vascular permeability, promotes leukocyte migration, and induces adhesion molecule expression. Thrombin as a potent signaling molecule is strongly implicated in a number of proinflammatory disorders including severe sepsis, cancer, cardiovascular disease, and of special interest in this review neurodegenerative disorders. This review summarizes the role of thrombin in the pathogenesis of central nervous system (CNS) inflammatory diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), promoting greater understanding and clinical management of these diseases. J. Cell. Physiol. 232: 482–485, 2017. © 2016 Wiley Periodicals, Inc.