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Neuronatin Protein in Health and Disease
Author(s) -
Pitale Priyamvada M.,
Howse Wayne,
Gorbatyuk Marina
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25498
Subject(s) - pathological , disease , neuroscience , biology , phospholamban , psychology , medicine , microbiology and biotechnology , pathology , phosphorylation
Neuronatin (NNAT) was first identified as a brain‐specific gene crucial for brain development. Over the years, NNAT has been studied in different developing and post‐developed tissues and organs. While NNAT manifests functional and structural similarities to the phospholamban gene, its physiological and pathological roles in healthy and diseased tissues have not been precisely identified. Ca 2+ signaling, glucose transport, insulin secretion, and inflammation modulated at different pathological conditions have been proposed to be governed by NNAT. This review describes the current findings of cellular molecular pathways known to be modified concomitantly with an alteration in NNAT expression, and it highlights the need to conduct extensive investigation regarding the role of NNAT in health and disease. J. Cell. Physiol. 232: 477–481, 2017. © 2016 Wiley Periodicals, Inc.