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Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?
Author(s) -
Cartocci Veronica,
Servadio Michela,
Trezza Viviana,
Pallottini Valentina
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25488
Subject(s) - cholesterol , neuroscience , cell function , central nervous system , affect (linguistics) , function (biology) , brain function , metabolism , synapse , mechanism (biology) , cell , lipid metabolism , biology , medicine , psychology , microbiology and biotechnology , endocrinology , biochemistry , philosophy , communication , epistemology
Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In recent years, the role of cholesterol in the brain has caught the attention of several research groups since a breakdown of cholesterol metabolism has been associated with different neurodevelopmental and neurodegenerative diseases, and interestingly also with psychiatric conditions. The aim of this review is to summarize the current knowledge about the connection between cholesterol dysregulation and various neurologic and psychiatric disorders based on clinical and preclinical studies. J. Cell. Physiol. 232: 281–286, 2017. © 2016 Wiley Periodicals, Inc.