Premium
Further Support for ECM Control of Receptor Trafficking and Signaling
Author(s) -
Clegg Lindsay,
Mac Gabhann Feilim
Publication year - 2017
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25464
Subject(s) - internalization , fibronectin , extracellular matrix , microbiology and biotechnology , receptor , matrix (chemical analysis) , vegf receptors , chemistry , signal transduction , biology , biochemistry , cancer research , chromatography
Recently, Sack et al. (2016) presented an interesting, novel data set in Journal of Cellular Physiology examining the effect of substrate stiffness on VEGF processing and signaling. The data represent a clear contribution to the field. However, the authors’ conclusion that “extracellular matrix binding is essential for VEGF internalization” conflicts with other knowledge in the field, and is not supported by their data. Instead, their data demonstrate the effect of heparin addition and changing ECM stiffness on both VEGF binding to fibronectin and VEGF binding to endothelial receptors. This is consistent with other work showing that matrix binding reduces VEGF‐VEGFR internalization, shifting downstream signaling. J. Cell. Physiol. 232: 36–37, 2017. © 2016 Wiley Periodicals, Inc.