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iPSCs, a Future Tool for Therapeutic Intervention in Mitochondrial Disorders: Pros and Cons
Author(s) -
Galera Teresa,
ZuritaDíaz Francisco,
Garesse Rafael,
Gallardo M. Esther
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25386
Subject(s) - cons , induced pluripotent stem cell , intervention (counseling) , mitochondrial disease , psychology , medicine , neuroscience , biology , mitochondrial dna , psychiatry , computer science , genetics , embryonic stem cell , gene , programming language
Mitochondrial disorders, although individually are rare, taken together constitute a big group of diseases that share a defect in the oxidative phosphorylation system. Up to now, the development of therapies for these diseases is very slow and ineffective due in part to the lack of appropriate disease models. Therefore, there is an urgent need for the discovery of new therapeutic interventions. Regarding this, the generation of induced pluripotent stem cells (iPSCs) has opened new expectations in the regenerative medicine field. However, special cares and considerations must be taken into account previous to a replacement therapy. J. Cell. Physiol. 231: 2317–2318, 2016. © 2016 Wiley Periodicals, Inc.