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Reprogramming for Cardiac Regeneration—Strategies for Innovation
Author(s) -
SanchisGomar Fabian,
Galera Teresa,
Lucia Alejandro,
Gallardo María Esther
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25311
Subject(s) - reprogramming , transdifferentiation , regeneration (biology) , telomerase , myocardial infarction , induced pluripotent stem cell , disease , heart failure , biology , bioinformatics , medicine , stem cell , cardiology , cell , microbiology and biotechnology , gene , genetics , embryonic stem cell
It is well‐known that the human myocardium has a low capacity for self‐regeneration. This fact is especially important after acute myocardial infarction with subsequent heart failure and adverse tissue remodeling. New potential strategies have recently emerged for treating heart diseases, such as the possibility of generating large quantities of cardiomyocytes through genetic iPSC reprogramming, transdifferentiation for in vitro disease modeling, in vivo therapies or telomerase gene reactivation. Approaches based on these techniques may represent the new horizon in cardiology with an appropriate 180‐degree turn perspective. J. Cell. Physiol. 231: 1849–1851, 2016. © 2016 Wiley Periodicals, Inc.