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New Treatment of Medullary and Papillary Human Thyroid Cancer: Biological Effects of Hyaluronic Acid Hydrogel Loaded With Quercetin Alone or in Combination to an Inhibitor of Aurora Kinase
Author(s) -
Quagliariello Vincenzo,
Armenia Emilia,
Aurilio Caterina,
Rosso Francesco,
Clemente Ottavia,
de Sena Gabriele,
Barbarisi Manlio,
Barbarisi Alfonso
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25283
Subject(s) - hyaluronic acid , cd44 , medullary thyroid cancer , chemistry , quercetin , pharmacology , cancer cell , kinase , thyroid cancer , cancer research , viability assay , cell , cancer , antioxidant , biochemistry , medicine , anatomy
The aim of this paper is based on the use of a hyaluronic acid hydrogel of Quercetin tested alone and in combination to an inhibitor of Aurora Kinase type A and B (SNS‐314) on human medullary and papillary thyroid cancer cells. Biological investigations were focused on the cellular uptake of the hydrogel, cell viability, antioxidant, and cytokines secretion studies. Quercetin delivered from hydrogel show a time and CD44 dependent interaction with both cell lines with significant anti‐inflammatory effects. Combination of Quercetin and SNS‐314 leads to a synergistic cytotoxic effect on medullary TT and papillary BCPAP cell lines with a significant reduction of the IC50 value. These results, highlights the importance of synergistic effect of the hyaluronic acid hydrogel of Quercetin with SNS‐314 in the regulation of human thyroid cancer cell proliferation and emphasize the anti‐tumor activity of these molecules. J. Cell. Physiol. 231: 1784–1795, 2016. © 2015 Wiley Periodicals, Inc.