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Common and Rare Genetic Variants Associated With Alzheimer's Disease
Author(s) -
Marei Hany E.,
Althani Asmaa,
Suhonen Jaana,
El Zowalaty Mohamed E.,
Albanna Mohammad A.,
Cenciarelli Carlo,
Wang Tengfei,
Caceci Thomas
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25225
Subject(s) - genome wide association study , disease , biology , single nucleotide polymorphism , exome sequencing , genetic association , genetics , exome , dna sequencing , computational biology , genome , bioinformatics , gene , medicine , mutation , genotype , pathology
Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome‐wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD‐related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets. J. Cell. Physiol. 231: 1432–1437, 2016. © 2015 Wiley Periodicals, Inc.