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Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV‐Infected Patients
Author(s) -
Kadri Ferdous,
LaPlante Andrea,
De Luca Mariacristina,
Doyle Lisa,
VelascoGonzalez Cruz,
Patterson Jonathan R.,
Molina Patricia E.,
Nelson Steve,
Zea Arnold H.,
Parsons Christopher H.,
Peruzzi Francesca
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25131
Subject(s) - neurocognitive , microrna , psychosocial , disease , human immunodeficiency virus (hiv) , depression (economics) , medicine , psychological intervention , cognition , dementia , pathological , cognitive impairment , immunology , bioinformatics , oncology , psychiatry , biology , gene , genetics , macroeconomics , economics
Human Immunodeficiency Virus (HIV)‐infected individuals are at increased risk for developing neurocognitive disorders and depression. These conditions collectively affect more than 50% of people living with HIV/AIDS and adversely impact adherence to HIV therapy. Thus, identification of early markers of neurocognitive impairment could lead to interventions that improve psychosocial functioning and slow or reverse disease progression through improved treatment adherence. Evidence has accumulated for the role and function of microRNAs in normal and pathological conditions. We have optimized a protocol to profile microRNAs in body fluids. Using this methodology, we have profiled plasma microRNA expression for 30 age‐matched, HIV‐infected (HIV + ) patients and identified highly sensitive and specific microRNA signatures distinguishing HIV + patients with cognitive impairment from those without cognitive impairment. These results justify follow‐on studies to determine whether plasma microRNA signatures can be used as a screening or prognostic tool for HIV + patients with neurocognitive impairment. J. Cell. Physiol. 231: 829–836, 2016. © 2015 Wiley Periodicals, Inc.