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Potential for Stem Cell‐Based Periodontal Therapy
Author(s) -
Bassir Seyed Hossein,
Wisitrasameewong Wichaya,
Raanan Justin,
Ghaffarigarakani Sasan,
Chung Jamie,
Freire Marcelo,
Andrada Luciano C.,
Intini Giuseppe
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25067
Subject(s) - cementum , periodontium , periodontal fiber , regeneration (biology) , stem cell , stem cell therapy , medicine , periodontal ligament stem cells , periodontal disease , dentistry , bioinformatics , mesenchymal stem cell , biology , pathology , microbiology and biotechnology , biochemistry , alkaline phosphatase , dentin , enzyme
Periodontal diseases are highly prevalent and are linked to several systemic diseases. The goal of periodontal treatment is to halt the progression of the disease and regenerate the damaged tissue. However, achieving complete and functional periodontal regeneration is challenging because the periodontium is a complex apparatus composed of different tissues, including bone, cementum, and periodontal ligament. Stem cells may represent an effective therapeutic tool for periodontal regeneration due to their plasticity and their ability to regenerate different tissues. This review presents and critically analyzes the available information on stem cell‐based therapy for the regeneration of periodontal tissues and suggests new avenues for the development of more effective therapeutic protocols. J. Cell. Physiol. 230: 50–61, 2016. © 2015 Wiley Periodicals, Inc.