Premium
Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells
Author(s) -
Kumar Vinit,
Bayda Samer,
Hadla Mohamad,
Caligiuri Isabella,
Russo Spena Concetta,
Palazzolo Stefano,
Kempter Susanne,
Corona Giuseppe,
Toffoli Giuseppe,
Rizzolio Flavio
Publication year - 2016
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25057
Subject(s) - doxorubicin , cancer cell , dna , cytotoxicity , biocompatibility , nanostructure , drug delivery , nanotechnology , cancer , cancer research , chemistry , materials science , chemotherapy , biology , biochemistry , in vitro , genetics , organic chemistry
In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular, in the last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis and ability to deliver drugs to cancer cells. Here, an open‐caged pyramidal DNA@Doxorubicin (Py‐Doxo) nanostructure was constructed with 10 DNA sequences of 26–28 nucleotides for drug delivery to cancer cells. The synthesized DNA nanostructures are sufficiently stable in biological medium. Py‐Doxo exhibited significantly enhanced cytotoxicity of the delivered doxorubicin to breast and liver cancer cells up to twofold compared to free doxorubicin. This study demonstrates the importance of the shape and structure of the designed transporter DNA nanostructures for biomedical applications. J. Cell. Physiol. 230: 106–110, 2016. © 2015 Wiley Periodicals, Inc.