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The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases
Author(s) -
Eisenstein Anna,
Patterson Shenia,
Ravid Katya
Publication year - 2015
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25043
Subject(s) - adenosine , adenosine receptor , receptor , biology , medicine , endocrinology , agonist
Modulation of the low affinity adenosine receptor subtype, the A2b adenosine receptor (A2bAR), has gained interest as a therapeutic target in various pathologic areas associated with cardiovascular disease. The actions of the A2bAR are diverse and at times conflicting depending on cell and tissue type and the timing of activation or inhibition of the receptor. The A2bAR is a promising and exciting pharmacologic target, however, a thorough understanding of A2bAR action is necessary to reach the therapeutic potential of this receptor. This review will focus on the role of the A2bAR in various cardiovascular and metabolic pathologies in which the receptor is currently being studied. We will illustrate the complexities of A2bAR signaling and highlight areas of research with potential for therapeutic development. J. Cell. Physiol. 230: 2891–2897, 2015. © 2015 Wiley Periodicals, Inc.