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Coalition of Nuclear Receptors in the Nervous System
Author(s) -
Förthmann Benjamin,
Aletta John M.,
Lee YuWei,
Terranova Chris,
Birkaya Barbara,
Stachowiak Ewa K.,
Stachowiak Michal K.,
Claus Peter
Publication year - 2015
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.25036
Subject(s) - receptor tyrosine kinase , nuclear receptor , fibroblast growth factor , biology , microbiology and biotechnology , fibroblast growth factor receptor 1 , neuroscience , nerve growth factor , dopaminergic , receptor , signal transduction , transcription factor , gene , genetics , dopamine
A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post‐mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non‐canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons. J. Cell. Physiol. 230: 2875–2880, 2015. © 2015 Wiley Periodicals, Inc.